Public Class Form1
Dim _originClienSize As Size = Nothing
Dim _originBtnSize As Size
Dim _originBtnPos As Point
Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load
'必须使用ClientSize，不能使用Size，因为Size包括窗口框架的宽高，这个是固定值，不能计算到缩放因素里
'不然当缩小到一定程度时，控件的大小和位置计算比例就不对了
_originClienSize = ClientSize
_originBtnSize = Button2.Size
_originBtnPos = Button2.Location
End Sub
Private Sub Form1_Resize(sender As Object, e As EventArgs) Handles MyBase.Resize
If _originClienSize <> Nothing Then
Button2.Width = ClientSize.Width / _originClienSize.Width * _originBtnSize.Width
Button2.Height = ClientSize.Height / _originClienSize.Height * _originBtnSize.Height
Dim point As Point = New Point(ClientSize.Width / _originClienSize.Width * _originBtnPos.X, ClientSize.Height / _originClienSize.Height * _originBtnPos.Y)
Button2.Location = point
End If
End Sub
End Class
效果